Ercc5<tm1Shm> Targeted Allele Detail MGI Mouse (MGI:2182793)

Ercc5^tm1Shm
Targeted Allele Detail

Summary

Symbol:	Ercc5^tm1Shm
Name:	excision repair cross-complementing rodent repair deficiency, complementation group 5; targeted mutation 1, Tadahiro Shiomi
MGI ID:	MGI:2182793
Synonyms:	Xpg-delta
Gene:	Ercc5 Location: Chr1:44186904-44220420 bp, + strand Genetic Position: Chr1, 23.55 cM, cytoband B
Alliance:	Ercc5^tm1Shm page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:53756
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Exon 3 was disrupted by the insertion of a neomycin selection cassette. Neither normal nor truncated transcript was detected by Northern blot analysis of total RNA obtained from newborn homozygous mutant mice. (J:53756)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ercc5 Mutation:	55 strains or lines available

References

Original:	J:53756 Harada YN, et al., Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene. Mol Cell Biol. 1999 Mar;19(3):2366-72
All:	3 reference(s)

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