Mtf1tm1Wsc
Targeted Allele Detail
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| Symbol: |
Mtf1tm1Wsc |
| Name: |
metal response element binding transcription factor 1; targeted mutation 1, Walter Schaffner |
| MGI ID: |
MGI:2182939 |
| Synonyms: |
MTF-1- |
| Gene: |
Mtf1 Location: Chr4:124696342-124743593 bp, + strand Genetic Position: Chr4, 57.91 cM, cytoband D1
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| Alliance: |
Mtf1tm1Wsc page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:48216
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| Parent Cell Line: |
GS1 (ES Cell)
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| Strain of Origin: |
129/Sv
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced sequences encoding the first two and a portion of the third zinc-finger domain. RT-PCR analysis of RNA from mutant embryos revealed the presence of an amino-terminal fragment, truncating 39 base pairs downstream of the 5' insertion point. The truncated transcript lacks sequence encoding 3 zinc-finger domains and the acidic, proline-rich, and serine/threonine-rich regions.
(J:19100, J:48216)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mtf1 Mutation: |
38 strains or lines available
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| Original: |
J:48216 Gunes C, et al., Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 1998 May 15;17(10):2846-54 |
| All: |
6 reference(s) |
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Analysis Tools
