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Tifa Gene Detail
Summary
  • Symbol
    Tifa
  • Name
    TRAF-interacting protein with forkhead-associated domain
  • Synonyms
    T2bp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182965
    NCBI Gene: 211550
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:127582524-127592043 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 56.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182965
 protein coding gene Chr3:127582524-127625813 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027865
 protein coding gene Chr3:130301327-130345372 (+)
A/J MGP_AJ_G0027823
 protein coding gene Chr3:125833275-125877011 (+)
AKR/J MGP_AKRJ_G0027788
 protein coding gene Chr3:129088831-129132706 (+)
BALB/cJ MGP_BALBcJ_G0027836
 protein coding gene Chr3:125695068-125738024 (+)
C3H/HeJ MGP_C3HHeJ_G0027565
 protein coding gene Chr3:129462918-129509802 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028280
 protein coding gene Chr3:134998575-135043864 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025618
 protein coding gene Chr3:121079034-121121453 (+)
CAST/EiJ MGP_CASTEiJ_G0027022
 protein coding gene Chr3:129034809-129078557 (+)
CBA/J MGP_CBAJ_G0027541
 protein coding gene Chr3:139563949-139612738 (+)
DBA/2J MGP_DBA2J_G0027682
 protein coding gene Chr3:125050862-125093313 (+)
FVB/NJ MGP_FVBNJ_G0027649
 protein coding gene Chr3:122637907-122679751 (+)
LP/J MGP_LPJ_G0027791
 protein coding gene Chr3:131847154-131895717 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027680
 protein coding gene Chr3:147496816-147556204 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028337
 protein coding gene Chr3:128729809-128781428 (+)
PWK/PhJ MGP_PWKPhJ_G0026746
 protein coding gene Chr3:124783289-124828837 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026571
 protein coding gene Chr3:126810567-126850277 (+)
WSB/EiJ MGP_WSBEiJ_G0027101
 protein coding gene Chr3:129450630-129499535 (+)



Homology
more
  • Human Ortholog
    TIFA, TRAF interacting protein with forkhead associated domain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIFA, TRAF interacting protein with forkhead associated domain
  • Synonyms
    T2BP, T6BP, TIFAA
  • Links
    NCBI Gene ID: 92610
    neXtProt AC: NX_Q96CG3
    UniProt: Q96CG3

  • Chr Location
    4q25; chr4:112272968-112285955 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    10
  • cDNA Data
    29
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 211550 NCBI Gene Model | MGI Sequence Detail 9520 C57BL/6J ±  kb
transcript NM_145133 RefSeq | MGI Sequence Detail 2183 C57BL/6  
polypeptide Q793I8 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 29

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory