Gabra2tm1Uru
Targeted Allele Detail
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| Symbol: |
Gabra2tm1Uru |
| Name: |
gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 1, Uwe Rudolph |
| MGI ID: |
MGI:2183161 |
| Synonyms: |
alpha2(H101R), mutant allele 1 |
| Gene: |
Gabra2 Location: Chr5:71115735-71253192 bp, - strand Genetic Position: Chr5, 37.59 cM
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| Alliance: |
Gabra2tm1Uru page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:65100
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Not Specified) |
| Mutations: |
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Insertion, Single point mutation
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Mutation details: A point mutation was introduced into codon 101 (exon 4) resulting in the substitution of histidine with arginine (H101R). The targeting vector also contained a floxed neomycin cassette in intron 3 for selection. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Gabra2tm1.1Uru.
(J:65100)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gabra2 Mutation: |
36 strains or lines available
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| Original: |
J:65100 Low K, et al., Molecular and neuronal substrate for the selective attenuation of anxiety. Science. 2000 Oct 6;290(5489):131-4 |
| All: |
5 reference(s) |
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Analysis Tools
