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Ror2tm1Ymi
Targeted Allele Detail
Summary
Symbol: Ror2tm1Ymi
Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, Yasuhiro Minami
MGI ID: MGI:2183225
Synonyms: mRor2-, Ror2-
Gene: Ror2  Location: Chr13:53263353-53440160 bp, - strand  Genetic Position: Chr13, 27.68 cM, cytoband B3
Alliance: Ror2tm1Ymi page
Ror2Y324C/Ror2Y324C and Ror2tm1Ymi/Ror2tm1Ymi mice exhibit short tails at E10.75

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60125
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons encoding an Ig-like domain with a neomycin resistance gene via homologous recombination. Western blot analysis confirmed the absence of protein expression in neural progenitor cells from homozygous mice. (J:60125, J:182150)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129P2/OlaHsd
 
hm2  Disease Model
involves: 129P2/OlaHsd * C57BL/6
 
involves: 129P2/OlaHsd * C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms
     
cardiovascular system
transposition of great arteries
ventricular septal defect
perimembraneous ventricular septal defect
cellular
decreased primordial germ cell number
abnormal primordial germ cell migration
craniofacial
abnormal cranium morphology
increased cranium width
abnormal jaw morphology
abnormal mandible morphology
abnormal mandibular angle morphology
abnormal mandibular condyloid process morphology
short mandible
abnormal maxilla morphology
abnormal middle ear ossicle morphology
abnormal malleus morphology
abnormal craniofacial development
abnormal Meckel's cartilage morphology
short Meckel's cartilage
abnormal nasal capsule morphology
midface hypoplasia
cleft secondary palate
failure of palatal shelf elevation
digestive/alimentary system
cleft secondary palate
failure of palatal shelf elevation
embryo
decreased embryo size
abnormal somite development
abnormal somite shape
abnormal somite size
small tail bud
growth/size/body
abnormal nasal capsule morphology
midface hypoplasia
cleft secondary palate
failure of palatal shelf elevation
decreased embryo size
hearing/vestibular/ear
abnormal middle ear ossicle morphology
abnormal malleus morphology
abnormal organ of Corti morphology
abnormal cochlear hair cell morphology
abnormal cochlear outer hair cell morphology
abnormal tegmen tympani morphology
homeostasis/metabolism
abnormal blood homeostasis
cyanosis
limbs/digits/tail
small tail bud
abnormal limb morphology
abnormal autopod morphology
brachyphalangia
brachydactyly
polydactyly
abnormal forelimb stylopod morphology
abnormal forelimb zeugopod morphology
short radius
short ulna
abnormal hindlimb stylopod morphology
abnormal hindlimb zeugopod morphology
short metacarpal bones
short tail
mortality/aging
neonatal lethality, complete penetrance
perinatal lethality, incomplete penetrance
nervous system
abnormal cochlear hair cell morphology
abnormal cochlear outer hair cell morphology
reproductive system
decreased primordial germ cell number
abnormal primordial germ cell migration
genital tubercle hypoplasia
respiratory system
abnormal nasal capsule morphology
abnormal pulmonary alveolus morphology
respiratory distress
skeleton
abnormal cranium morphology
increased cranium width
abnormal jaw morphology
abnormal mandible morphology
abnormal mandibular angle morphology
abnormal mandibular condyloid process morphology
short mandible
abnormal maxilla morphology
abnormal middle ear ossicle morphology
abnormal malleus morphology
abnormal long bone morphology
decreased length of long bones
brachyphalangia
short radius
short ulna
short metacarpal bones
absent sternum
abnormal pubic symphysis morphology
abnormal rib morphology
rib fusion
abnormal vertebrae morphology
abnormal sacral vertebrae morphology
sacral vertebral fusion
small sacral vertebrae
abnormal vertebrae development
abnormal cartilage morphology
abnormal Meckel's cartilage morphology
short Meckel's cartilage
abnormal nasal capsule morphology
abnormal cartilage development
abnormal long bone epiphyseal plate proliferative zone
decreased width of hypertrophic chondrocyte zone
abnormal chondrocyte morphology
delayed chondrocyte differentiation
delayed bone ossification
vision/eye
ocular hypertelorism
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
hm2
IDs
Expression
In Mice Carrying this Mutation: 76 assay results
In Structures Affected by this Mutation: 35 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ror2 Mutation:  126 strains or lines available
References
Original:  J:60125 Takeuchi S, et al., Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells. 2000 Jan;5(1):71-8
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory