Tnfrsf11atm1Wjb
Targeted Allele Detail
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| Symbol: |
Tnfrsf11atm1Wjb |
| Name: |
tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1, William J Boyle |
| MGI ID: |
MGI:2183226 |
| Synonyms: |
RANK- |
| Gene: |
Tnfrsf11a Location: Chr1:105708443-105775709 bp, + strand Genetic Position: Chr1, 49.7 cM
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| Alliance: |
Tnfrsf11atm1Wjb page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:77636
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| Parent Cell Line: |
RW-4 (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A portion of exon 2 and all of exon 3 was replaced with a neomycin selection cassette. The deleted region encoded approximately one and one half of the amino-terminal TNFR-like cysteine-rich domain, comprised of residues 34 through 96. Northern blot analysis confirmed the absence of normal transcript, while the results of a Western blot analysis of intestinal lysates using antibodies raised against the extracellular domain of the endogenous protien indicated a lack of protein.
(J:77636)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tnfrsf11a Mutation: |
42 strains or lines available
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| Original: |
J:77636 Li J, et al., RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1566-71 |
| All: |
6 reference(s) |
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Analysis Tools
