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Akr1b1tm1Skc
Targeted Allele Detail
Summary
Symbol: Akr1b1tm1Skc
Name: aldo-keto reductase family 1 member B; targeted mutation 1, Sookja K Chung
MGI ID: MGI:2183239
Synonyms: Aldor1-, AR-, AR-KO
Gene: Akr1b1  Location: Chr6:34280865-34294424 bp, - strand  Genetic Position: Chr6, 14.87 cM, cytoband B1
Alliance: Akr1b1tm1Skc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77647
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: 2.7kb of sequence, encompassing a portion of exon 5 and all of exons 6, 7, and 8, was replaced by a neomycin selection cassette. The absence of transcript and protein in homozygous mutant mice was determined via Northern blot and Western blot analyses of various tissues. (J:77647)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akr1b1 Mutation:  27 strains or lines available
References
Original:  J:77647 Ho HT, et al., Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. Mol Cell Biol. 2000 Aug;20(16):5840-6
All:  20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory