Fancg<tm1Ada> Targeted Allele Detail MGI Mouse (MGI:2183264)

Fancg^tm1Ada
Targeted Allele Detail

Summary

Symbol:	Fancg^tm1Ada
Name:	Fanconi anemia, complementation group G; targeted mutation 1, Alan D'Andrea
MGI ID:	MGI:2183264
Synonyms:	Fancg^-
Gene:	Fancg Location: Chr4:43002343-43010506 bp, - strand Genetic Position: Chr4, 22.97 cM, cytoband B1
Alliance:	Fancg^tm1Ada page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:72945
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 2-9 were replaced with an FRT-flanked neo cassette via homologous recombination. The targeting vector introduces stop codons in all 3 reading frames. Gene transcripts were absent in testes from homozygous mutant animals as assayed by RT-PCR analysis using primers to exons 5 and 6. (J:72945)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Fancg^tm1Ada

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fancg Mutation:	37 strains or lines available

References

Original:	J:72945 Yang Y, et al., Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9. Blood. 2001 Dec 1;98(12):3435-40
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24