Stxbp1<tm1Sud> Targeted Allele Detail MGI Mouse (MGI:2183278)

Stxbp1^tm1Sud
Targeted Allele Detail

Summary

Symbol:	Stxbp1^tm1Sud
Name:	syntaxin binding protein 1; targeted mutation 1, Thomas C Sudhoff
MGI ID:	MGI:2183278
Synonyms:	munc18-1^-
Gene:	Stxbp1 Location: Chr2:32677619-32737249 bp, - strand Genetic Position: Chr2, 22.09 cM
Alliance:	Stxbp1^tm1Sud page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:77237
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Five exons, encoding amino acids 14 through 144, were replaced with a neomycin selection cassette. Neither transcript nor protein was detected in homozygous mice by Northern blot or Western blot analyses. (J:77237)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	110 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Stxbp1 Mutation:	48 strains or lines available

Notes

The targeting vector was electroporated into "G-cell" ES cells.

References

Original:	J:77237 Verhage M, et al., Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science. 2000 Feb 4;287(5454):864-9
All:	35 reference(s)

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