Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol: Runx3tm1Yg Name: runt related transcription factor 3; targeted mutation 1, Yoram Groner MGI ID: MGI:2183399 Synonyms: Rehovot-Runx3Lacz, Runx3-, Runx3LacZ Gene: Runx3  Location: Chr4:134847963-134905301 bp, + strand  Genetic Position: Chr4, 67.19 cM Alliance: Runx3tm1Yg page

Pathological findings in large intestines of Runx3tm1Yg/Runx3tm1Yg and +/+ wild-type. Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:77764
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Exon 2, encoding the runt domain, was disrupted by the insertion of a cassette containing IRES-lacZ and neo. RT-PCR analysis of dorsal root ganglia RNA extracts showed an absence of transcript in homozygous mutant mice. Protein was undetected by Western blot analysis of thymus tissue and immunostaining of dorsal root ganglia. Expression of beta-galactosidase was visualized in mutant embryos via X-gal staining. (J:77764)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	34 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx3 Mutation:	27 strains or lines available

Original:	J:77764 Levanon D, et al., The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002 Jul 1;21(13):3454-63
All:	26 reference(s)