About   Help   FAQ
Vdrtm1.1Gcm
Targeted Allele Detail
Summary
Symbol: Vdrtm1.1Gcm
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1.1, Geert Carmeliet
MGI ID: MGI:2183409
Synonyms: Leuven VDR-KO
Gene: Vdr  Location: Chr15:97752308-97806177 bp, - strand  Genetic Position: Chr15, 53.85 cM
Alliance: Vdrtm1.1Gcm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72578
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: The targeted mutation is a derivative of Vdrtm1Gcm. Exon 2 was deleted by crossing animals carrying Vdrtm1Gcm to a cre-expressing line. Absence of gene expression in homozygous mutant animals was demonstrated by RT-PCR analysis of duodenum, kidney, and bone tissue. (J:72578)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 50 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vdr Mutation:  36 strains or lines available
References
Original:  J:72578 Van Cromphaut SJ, et al., Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13324-9
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory