Gjb2<tm1Ugds> Targeted Allele Detail MGI Mouse (MGI:2183509)

Gjb2^tm1Ugds
Targeted Allele Detail

Summary

Symbol:	Gjb2^tm1Ugds
Name:	gap junction protein, beta 2; targeted mutation 1, Unite de Genetique des Deficits Sensoriels
MGI ID:	MGI:2183509
Synonyms:	Cx26^fl, Cx26fl, Cx26^loxP, Gjb2^tm1Ptt
Gene:	Gjb2 Location: Chr14:57336059-57342159 bp, - strand Genetic Position: Chr14, 30.1 cM, cytoband D1-E1
Alliance:	Gjb2^tm1Ugds page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:77823
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1^b-m3

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: The coding region in exon 2 was flanked by a loxP site in intron 1 and a floxed neo cassette inserted into exon 2. Immunohistofluorescence analysis showed that the expression pattern of this floxed allele did not differ from that of wild-type. (J:77823)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Gjb2 Mutation:	22 strains or lines available

References

Original:	J:77823 Cohen-Salmon M, et al., Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr Biol. 2002 Jul 9;12(13):1106-11
All:	41 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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