Agttm1Ii
Targeted Allele Detail
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| Symbol: |
Agttm1Ii |
| Name: |
angiotensinogen; targeted mutation 1, Iekuni Ichikawa |
| MGI ID: |
MGI:2183545 |
| Synonyms: |
Agt-, Angt-KO |
| Gene: |
Agt Location: Chr8:125283326-125296445 bp, - strand Genetic Position: Chr8, 72.81 cM
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| Alliance: |
Agttm1Ii page
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Abnormal kidney morphology in 3 week old Agttm1Ii/Agttm1Ii mice
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:30061
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 1.5 kb region of the gene containing exon 2 was replaced with a PGK-neo cassette via homologous recombination. Exon 2 encodes the translation start site and the entire octapeptide region of the protein. Absence of gene expression was confirmed in homozygous mutant animals by Northern blot analysis of liver tissue. Furthermore, no plasma angiotensinogen could be detected in homozygous mutant animals.
(J:30061)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129P2/OlaHsd * C57BL/6 | | | | involves: 129P2/OlaHsd * C57BL/6 | |
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| Phenotypes: |
| Affected Systems |
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behavior/neurological
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increased fluid intake
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cardiovascular system
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abnormal kidney afferent arteriole morphology
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abnormal kidney cortex artery morphology
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abnormal kidney interlobular artery morphology
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decreased heart weight
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decreased systemic arterial blood pressure
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decreased systemic arterial systolic blood pressure
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growth/size/body
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abnormal postnatal growth/weight/body size
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homeostasis/metabolism
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increased circulating creatinine level
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decreased urine osmolality
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liver/biliary system
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decreased liver weight
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renal/urinary system
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abnormal kidney morphology
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dilated kidney collecting duct
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abnormal kidney cortex morphology
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abnormal kidney afferent arteriole morphology
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√
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abnormal kidney cortex artery morphology
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abnormal kidney interlobular artery morphology
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abnormal renal glomerulus morphology
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expanded mesangial matrix
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renal interstitial fibrosis
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kidney papillary atrophy
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kidney papillary hypoplasia
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hydronephrosis
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dilated renal tubule
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abnormal renal/urinary system physiology
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decreased urine osmolality
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√
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abnormal renal filtration rate
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√
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increased urine flow rate
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Agt Mutation: |
35 strains or lines available
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| Original: |
J:30061 Niimura F, et al., Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest. 1995 Dec;96(6):2947-54 |
| All: |
6 reference(s) |
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Analysis Tools
