Myo3a MGI Mouse Gene Detail - MGI:2183924

Symbol

Myo3a
Name

myosin IIIA
Synonyms

9030416P08Rik

Feature Type

protein coding gene
IDs

MGI:2183924
NCBI Gene: 667663
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:22232314-22508264 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 15.15 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

7666 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2183924	protein coding gene	Chr2:22232314-22508693 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025390	protein coding gene	Chr2:20051632-20327105 (+)
A/J	MGP_AJ_G0025368	protein coding gene	Chr2:19236661-19506399 (+)
AKR/J	MGP_AKRJ_G0025336	protein coding gene	Chr2:19904229-20205272 (+)
BALB/cJ	MGP_BALBcJ_G0025363	protein coding gene	Chr2:19329206-19618562 (+)
C3H/HeJ	MGP_C3HHeJ_G0025123	protein coding gene	Chr2:19828851-20113648 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025806	protein coding gene	Chr2:20634019-20924201 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023221	protein coding gene	Chr2:18380986-18610095 (+)
CAST/EiJ	MGP_CASTEiJ_G0024587	protein coding gene	Chr2:19755177-20035162 (+)
CBA/J	MGP_CBAJ_G0025102	protein coding gene	Chr2:21410232-21717029 (+)
DBA/2J	MGP_DBA2J_G0025234	protein coding gene	Chr2:19153091-19408545 (+)
FVB/NJ	MGP_FVBNJ_G0025197	protein coding gene	Chr2:18935766-19196708 (+)
LP/J	MGP_LPJ_G0025321	protein coding gene	Chr2:19850101-20275571 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025228	protein coding gene	Chr2:21417486-21771017 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025864	protein coding gene	Chr2:19799942-20084918 (+)
PWK/PhJ	MGP_PWKPhJ_G0024336	protein coding gene	Chr2:18964162-19221099 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024136	protein coding gene	Chr2:19946334-20216149 (+)
WSB/EiJ	MGP_WSBEiJ_G0024657	protein coding gene	Chr2:19851275-20238498 (+)

Human Ortholog

MYO3A, myosin IIIA

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO3A, myosin IIIA
Synonyms

DFNA90, DFNB30
Links

HGNC:7601

NCBI Gene ID: 53904

neXtProt AC: NX_Q8NEV4

UniProt: Q8NEV4
Chr Location

10p12.1; chr10:25934229-26212532 (+) GRCh38

MGI Vertebrate Homology

Myo3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MYO3A
Gene Tree

Myo3a

Diseases

1 with Myo3a mouse models; 2 with human MYO3A associations

Human Disease

Mouse Models

autosomal recessive nonsyndromic deafness 30

IDs

View 1 model

autosomal dominant nonsyndromic deafness

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

110 strains or lines available

Mice homozygous for a nonsense mutation characteristic of human DFNB30 exhibit progressive hearing loss and cochlear hair cell degeneration. Mice homozygous for a null allele show normal hair bundle organization/structure in auditory organs, normal hearing thresholds, and no overt vestibular dysfunction.

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All GO Annotations

85
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

6
cDNA Data

3
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN myo3a

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All Sequences

37
RefSeq

2
UniProt

4
CCDS

CCDS84477.1

Ensembl

ENSMUSG00000025716 (Evidence)
NCBI Gene

667663

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025716	Ensembl Gene Model \| MGI Sequence Detail	275951	C57BL/6J	± kb
transcript	ENSMUST00000044749	Ensembl \| MGI Sequence Detail	5082	Not Applicable
polypeptide	ENSMUSP00000046329	Ensembl \| MGI Sequence Detail	1621	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010863 myosin-IIIa

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR036083 Class III myosin, motor domain

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain

IPR052409 Myosin-III family with kinase activity

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 4

cDNA 3

Primer pair 1

Microarray probesets 2

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MGI:1918799

Summaries

All 39

Developmental Gene Expression 3

Diseases 1

Gene Ontology 13

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myo3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16475	Chr2:22232351-22232393 (+)	58 bp
Tssr16476	Chr2:22478993-22479023 (+)	246,694 bp
Tssr16477	Chr2:22479043-22479055 (+)	246,735 bp
Tssr423	Chr2:22479162-22479171 (+)	246,853 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24