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Mapk8tm1Wag
Targeted Allele Detail
Summary
Symbol: Mapk8tm1Wag
Name: mitogen-activated protein kinase 8; targeted mutation 1, Erwin F Wagner
MGI ID: MGI:2384141
Synonyms: Jnk1-
Gene: Mapk8  Location: Chr14:33099855-33169115 bp, - strand  Genetic Position: Chr14, 20.22 cM, cytoband B
Alliance: Mapk8tm1Wag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78190
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 3' region of exon 2, which encodes a portion of the kinase domain, was deleted by the in frame insertion of a cassette containing lacZ along with neo. The absence of both known isoforms encoded by the endogenous locus was confirmed by Western blot analysis of homozygous mutant mouse embyronic fibroblasts. (J:78190)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk8 Mutation:  74 strains or lines available
References
Original:  J:78190 Sabapathy K, et al., c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J Exp Med. 2001 Feb 5;193(3):317-28
All:  43 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory