Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Cdkn2atm2.1Rdp
Name:	cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Ronald DePinho
MGI ID:	MGI:2384177
Synonyms:	Ink4a-, p16-, p16Ink4a-, p16Ink4a-
Gene:	Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance:	Cdkn2atm2.1Rdp page

Germline Transmission:	Earliest citation of germline transmission: J:71394
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 alpha, specific to the p16Ink4a alternative splice product, was replaced by a floxed neo cassette. Cre mediated recombination removed the floxed neo cassette. The absence of the p16Ink4a and the presence of p19ARF was confirmed by Western blot analysis of extracts from homozygous mutant mouse embryonic fibroblasts. (J:71394)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdkn2atm2.1Rdp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:	67 strains or lines available

Original:	J:71394 Sharpless NE, et al., Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 2001 Sep 6;413(6851):86-91
All:	86 reference(s)