Mlh3<tm1Lpkn> Targeted Allele Detail MGI Mouse (MGI:2384218)

Mlh3^tm1Lpkn
Targeted Allele Detail

Summary

Symbol:	Mlh3^tm1Lpkn
Name:	mutL homolog 3; targeted mutation 1, Steven M Lipkin
MGI ID:	MGI:2384218
Synonyms:	Mlh3^-
Gene:	Mlh3 Location: Chr12:85281294-85317373 bp, - strand Genetic Position: Chr12, 39.61 cM
Alliance:	Mlh3^tm1Lpkn page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:78200
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 2 and downstream intronic sequence were replaced with a cassette containing lacZ and neo. Transcript was undetected by Nothern blot analysis of total testicular RNA. Immunofluorescence analysis of chromosomes during the meiosis I pachytene stage showed an absence of protein in homozygous mutant mice. (J:78200)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mlh3^tm1Lpkn

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Mlh3 Mutation:	78 strains or lines available

References

Original:	J:78200 Lipkin SM, et al., Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet. 2002 Aug;31(4):385-90
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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