Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ppargtm1.1Gonz
Name:	peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Frank J Gonzales
MGI ID:	MGI:2384321
Synonyms:	PPARgammafl
Gene:	Pparg  Location: Chr6:115337912-115467360 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Alliance:	Ppargtm1.1Gonz page

Germline Transmission:	Earliest citation of germline transmission: J:75777
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Animals heterozygous for Ppargtm1Gonz were crossed to an EIIa-cre transgenic line to delete the floxed PGK-neo cassette. The deletion event leaves behind single loxP sites flanking exon 2. Southern blot analysis confirmed the removal of PGK-neo in offspring. (J:75777)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

List all tumor models in MMHCdb carrying Ppargtm1.1Gonz

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:	41 strains or lines available

Original:	J:75777 Akiyama TE, et al., Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002 Apr;22(8):2607-19
All:	83 reference(s)