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Foxa1tm1Stf
Targeted Allele Detail
Summary
Symbol: Foxa1tm1Stf
Name: forkhead box A1; targeted mutation 1, Markus Stoffel
MGI ID: MGI:2384404
Synonyms: HNF-3alpha-
Gene: Foxa1  Location: Chr12:57587414-57593702 bp, - strand  Genetic Position: Chr12, 24.7 cM
Alliance: Foxa1tm1Stf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57493
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The in frame insertion of a cassette containing lacZ and neo genes replaced the majority of exon 2. The deleted region encoded the DNA-binding domain. Transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:57493)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxa1 Mutation:  21 strains or lines available
References
Original:  J:57493 Shih DQ, et al., Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10152-7
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory