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Il27 Gene Detail
Summary
  • Symbol
    Il27
  • Name
    interleukin 27
  • Synonyms
    IL-27, IL-27p28, Il30, p28
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384409
    NCBI Gene: 246779
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126188182-126194113 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384409
 protein coding gene Chr7:126188181-126194197 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032988
 protein coding gene Chr7:130872282-130878216 (-)
A/J MGP_AJ_G0032971
 protein coding gene Chr7:127409681-127415607 (-)
AKR/J MGP_AKRJ_G0032903
 protein coding gene Chr7:130632471-130638397 (-)
BALB/cJ MGP_BALBcJ_G0032976
 protein coding gene Chr7:127067160-127073091 (-)
C3H/HeJ MGP_C3HHeJ_G0032686
 protein coding gene Chr7:130562188-130568105 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033482
 protein coding gene Chr7:135962378-135968324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030454
 protein coding gene Chr7:128599363-128605540 (-)
CAST/EiJ MGP_CASTEiJ_G0032014
 protein coding gene Chr7:122355824-122361566 (-)
CBA/J MGP_CBAJ_G0032659
 protein coding gene Chr7:140534053-140539998 (-)
DBA/2J MGP_DBA2J_G0032811
 protein coding gene Chr7:125385643-125391572 (-)
FVB/NJ MGP_FVBNJ_G0032764
 protein coding gene Chr7:125235347-125241982 (-)
LP/J MGP_LPJ_G0032905
 protein coding gene Chr7:132337085-132343008 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032796
 protein coding gene Chr7:141722152-141728107 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033501
 protein coding gene Chr7:129649088-129654975 (-)
PWK/PhJ MGP_PWKPhJ_G0031722
 protein coding gene Chr7:118373716-118379775 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031568
 protein coding gene Chr7:116477690-116483631 (-)
WSB/EiJ MGP_WSBEiJ_G0032127
 protein coding gene Chr7:130616521-130622446 (-)



Homology
more
  • Human Ortholog
    IL27, interleukin 27
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL27, interleukin 27
  • Synonyms
    IL-27, IL-27A, IL27A, IL27p28, IL30, p28
  • Links
    NCBI Gene ID: 246778
    neXtProt AC: NX_Q8NEV9
    UniProt: Q8NEV9

  • Chr Location
    16p12.1-p11.2; chr16:28499362-28512051 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human IL27 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop an exaggerated delayed-type hypersensitivity response and are more susceptible to experimental autoimmune encephalomyelitis due to the presence of an increased number of Th17 cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    7
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044701 Ensembl Gene Model | MGI Sequence Detail 5932 C57BL/6J ±  kb
    transcript ENSMUST00000058429 Ensembl | MGI Sequence Detail 1021 Not Applicable  
    polypeptide ENSMUSP00000054637 Ensembl | MGI Sequence Detail 234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 38
    • Earliest
      J:77522 Pflanz S, et al., IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity. 2002 Jun;16(6):779-90
    • Latest
      J:350746 Bradford SD, et al., IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model. Front Immunol. 2024;15:1217098
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory