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Hnf1atm1.1Ylee
Targeted Allele Detail
Summary
Symbol: Hnf1atm1.1Ylee
Name: HNF1 homeobox A; targeted mutation 1.1, Ying-Hue Lee
MGI ID: MGI:2384429
Synonyms: hnf1alpha-, Hnf-1alpha-
Gene: Hnf1a  Location: Chr5:115087039-115109121 bp, - strand  Genetic Position: Chr5, 55.99 cM, cytoband F
Alliance: Hnf1atm1.1Ylee page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47008
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: This allele was generated by breeding mice carrying Tcf1tm1Ylee with transgenic mice expressing cre via the EIIa promoter. Cre mediated excision of the floxed fragment, containing the coding region of exon 1 and the neo transgene inserted into intron 1, resulted in the loss of sequence encoding 108 amino acids as well as a portion of intron 1. Transcript was undetected in homozygous mutant mice via RT-PCR analysis. (J:47008)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 32 assay results
4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hnf1a Mutation:  29 strains or lines available
References
Original:  J:47008 Lee YH, et al., Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol. 1998 May;18(5):3059-68
All:  28 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory