Tgfbr2<tm1Hlm> Targeted Allele Detail MGI Mouse (MGI:2384511)

Tgfbr2^tm1Hlm
Targeted Allele Detail

Summary

Symbol:	Tgfbr2^tm1Hlm
Name:	transforming growth factor, beta receptor II; targeted mutation 1, Harold L Moses
MGI ID:	MGI:2384511
Gene:	Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
Alliance:	Tgfbr2^tm1Hlm page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:75073
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready)
Mutation:		Insertion
		Mutation details: A construct, in which exon 2 was surrounded by a loxP site in intron 1 and a floxed neo gene in intron 2, was incorporated at the endogenous locus via homologous recombination. (J:75073)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfbr2^tm1Hlm

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Tgfbr2 Mutation:	40 strains or lines available

References

Original:	J:75073 Chytil A, et al., Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis. 2002 Feb;32(2):73-5
All:	41 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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