Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tgfbr2tm1.2Hlm
Name:	transforming growth factor, beta receptor II; targeted mutation 1.2, Harold L Moses
MGI ID:	MGI:2384513
Synonyms:	+Exon2/-Neor, floxed-Tbr2, TbetaRIIflox+, TbetaRIIflox, Tbr2fl, TGFbeta IIRfl, TGFbetaRIIf, Tgfbr2E2flx, Tgfbr2fl, Tgfbr2floxE2, Tgfbr2loxP, TgfbrfloxE2
Gene:	Tgfbr2  Location: Chr9:115916763-116004431 bp, - strand  Genetic Position: Chr9, 68.39 cM
Alliance:	Tgfbr2tm1.2Hlm page

Germline Transmission:	Earliest citation of germline transmission: J:75073
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: This allele is derived from Tgfbr2tm1Hlm. Expression of cre recombinase at the one cell stage resulted in the excision of the floxed region containing the neo transgene. Two single loxP sites were left flanking exon 2. (J:75073)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	135 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	33 anatomical structure(s)

List all tumor models in MMHCdb carrying Tgfbr2tm1.2Hlm

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbr2 Mutation:	40 strains or lines available

Original:	J:75073 Chytil A, et al., Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis. 2002 Feb;32(2):73-5
All:	195 reference(s)