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Ddx60 Gene Detail
Summary
  • Symbol
    Ddx60
  • Name
    DExD/H box helicase 60
  • Synonyms
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 60, MGC:19297
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384570
    NCBI Gene: 234311
  • Alliance
    gene page
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:62381155-62491278 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 31.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2660 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384570
 protein coding gene Chr8:62381121-62491278 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033637
 protein coding gene Chr8:61876383-61989486 (+)
A/J MGP_AJ_G0033619
 protein coding gene Chr8:59238455-59350642 (+)
AKR/J MGP_AKRJ_G0033544
 protein coding gene Chr8:60950426-61069019 (+)
BALB/cJ MGP_BALBcJ_G0033615
 protein coding gene Chr8:59486982-59602136 (+)
C3H/HeJ MGP_C3HHeJ_G0033325
 protein coding gene Chr8:61614511-61732433 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034132
 protein coding gene Chr8:64204419-64325059 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031080
 protein coding gene Chr8:54472732-54584812 (+)
CAST/EiJ MGP_CASTEiJ_G0032650
 protein coding gene Chr8:61026088-61143021 (+)
CBA/J MGP_CBAJ_G0033303
 protein coding gene Chr8:66563061-66694362 (+)
DBA/2J MGP_DBA2J_G0033457
 protein coding gene Chr8:58986954-59097791 (+)
FVB/NJ MGP_FVBNJ_G0033398
 protein coding gene Chr8:58292229-58403932 (+)
LP/J MGP_LPJ_G0033545
 protein coding gene Chr8:61844440-61969960 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033442
 protein coding gene Chr8:68632662-68752937 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034150
 protein coding gene Chr8:61202940-61315696 (+)
PWK/PhJ MGP_PWKPhJ_G0032359
 protein coding gene Chr8:58296818-58410380 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032767
 protein coding gene Chr8:61522167-61638909 (+)



Homology
more
  • Human Ortholog
    DDX60, DExD/H-box helicase 60
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX60, DExD/H-box helicase 60
  • Links
    NCBI Gene ID: 55601
    neXtProt AC: NX_Q8IY21
    UniProt: Q8IY21

  • Chr Location
    4q32.3; chr4:168216291-168325979 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal immunity to several viruses (IAV, EMCV, SINV) but increased susceptibility to VSV infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    3
  • cDNA Data
    24
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234311 NCBI Gene Model | MGI Sequence Detail 110124 C57BL/6J ±  kb
    transcript NM_001293783 RefSeq | MGI Sequence Detail 6503 C57BL/6  
    polypeptide NP_001280712 RefSeq | MGI Sequence Detail 1710 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR011545 DEAD/DEAH box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR052431 SKI2 subfamily ATP-dependent RNA helicases
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:236435 Goubau D, et al., Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses. Eur J Immunol. 2015 Dec;45(12):3386-403
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory