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Eif4g1 Gene Detail
Summary
  • Symbol
    Eif4g1
  • Name
    eukaryotic translation initiation factor 4, gamma 1
  • Synonyms
    E030015G23Rik, MGC:37551
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384784
    NCBI Gene: 208643
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20491457-20511633 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384784
 protein coding gene Chr16:20487063-20511634 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022651
 protein coding gene Chr16:18015713-18042822 (+)
A/J MGP_AJ_G0022613
 protein coding gene Chr16:17143703-17169691 (+)
AKR/J MGP_AKRJ_G0022588
 protein coding gene Chr16:17790676-17816756 (+)
BALB/cJ MGP_BALBcJ_G0022617
 protein coding gene Chr16:17301632-17326203 (+)
C3H/HeJ MGP_C3HHeJ_G0022382
 protein coding gene Chr16:17964723-17990381 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023068
 protein coding gene Chr16:18368851-18394915 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020586
 protein coding gene Chr16:17833232-17853621 (+)
CAST/EiJ MGP_CASTEiJ_G0021912
 protein coding gene Chr16:17939653-17964474 (+)
CBA/J MGP_CBAJ_G0022354
 protein coding gene Chr16:19116993-19144427 (+)
DBA/2J MGP_DBA2J_G0022486
 protein coding gene Chr16:17073300-17095981 (+)
FVB/NJ MGP_FVBNJ_G0022461
 protein coding gene Chr16:17111393-17137250 (+)
LP/J MGP_LPJ_G0022553
 protein coding gene Chr16:17741750-17766542 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022481
 protein coding gene Chr16:18790205-18814956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023079
 protein coding gene Chr16:17769597-17790354 (+)
PWK/PhJ MGP_PWKPhJ_G0021653
 protein coding gene Chr16:17339937-17366475 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021483
 protein coding gene Chr16:17562010-17588685 (+)
WSB/EiJ MGP_WSBEiJ_G0021956
 protein coding gene Chr16:17758207-17784262 (+)



Homology
more
  • Human Ortholog
    EIF4G1, eukaryotic translation initiation factor 4 gamma 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4G1, eukaryotic translation initiation factor 4 gamma 1
  • Synonyms
    EIF4F, EIF4G, EIF-4G1, EIF4GI, P220, PARK18
  • Links
    NCBI Gene ID: 1981
    neXtProt AC: NX_Q04637
    UniProt: Q04637

  • Chr Location
    3q27.1; chr3:184314495-184335358 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF4G1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an amino acid substitution (R1207H) are viable and fertile. Mice lacking the neuronal microexon exhibit social behavior abnormalities, learning and memory deficits, increased inhibitory synaptic conductance, and altered hippocampal synaptic plasticity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    5
  • cDNA Data
    478
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 208643 NCBI Gene Model | MGI Sequence Detail 20177 C57BL/6J ±  kb
    transcript NM_001403460 RefSeq | MGI Sequence Detail 5397 C57BL/6  
    polypeptide Q6NZJ6 UniProt | EBI | MGI Sequence Detail 1600 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 478
      cDNA 478

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2443563
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory