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Akr1d1 Gene Detail
Summary
  • Symbol
    Akr1d1
  • Name
    aldo-keto reductase family 1, member D1
  • Synonyms
    MGC:25814
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384785
    NCBI Gene: 208665
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:37507108-37545750 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 16.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    910 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384785
 protein coding gene Chr6:37506913-37551856 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030577
 protein coding gene Chr6:35758847-35798530 (+)
A/J MGP_AJ_G0030550
 protein coding gene Chr6:34227706-34262021 (+)
AKR/J MGP_AKRJ_G0030477
 protein coding gene Chr6:35331452-35365898 (+)
BALB/cJ MGP_BALBcJ_G0030560
 protein coding gene Chr6:34419574-34456191 (+)
C3H/HeJ MGP_C3HHeJ_G0030273
 protein coding gene Chr6:35328802-35363741 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031014
 protein coding gene Chr6:36659606-36710244 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028226
 protein coding gene Chr6:32144245-32181675 (+)
CAST/EiJ MGP_CASTEiJ_G0029675
 protein coding gene Chr6:35169492-35205969 (+)
CBA/J MGP_CBAJ_G0030251
 protein coding gene Chr6:38056003-38094271 (+)
DBA/2J MGP_DBA2J_G0030395
 protein coding gene Chr6:34060938-34095248 (+)
FVB/NJ MGP_FVBNJ_G0030349
 protein coding gene Chr6:33848617-33885014 (+)
LP/J MGP_LPJ_G0030482
 protein coding gene Chr6:35828588-35865519 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030385
 protein coding gene Chr6:40460288-40498737 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031044
 protein coding gene Chr6:35237212-35273118 (+)
PWK/PhJ MGP_PWKPhJ_G0029389
 protein coding gene Chr6:33689761-33726076 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029225
 protein coding gene Chr6:34923162-34961862 (+)
WSB/EiJ MGP_WSBEiJ_G0029751
 protein coding gene Chr6:35174274-35212222 (+)



Homology
more
  • Human Ortholog
    AKR1D1, aldo-keto reductase family 1 member D1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1D1, aldo-keto reductase family 1 member D1
  • Synonyms
    3o5bred, CBAS2, SRD5B1
  • Links
    NCBI Gene ID: 6718
    neXtProt AC: NX_P51857
    UniProt: P51857

  • Chr Location
    7q33; chr7:138002324-138118305 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AKR1D1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    110
  • cDNA Data
    12
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038641 Ensembl Gene Model | MGI Sequence Detail 38643 C57BL/6J ±  kb
transcript ENSMUST00000040987 Ensembl | MGI Sequence Detail 2699 Not Applicable  
polypeptide ENSMUSP00000048830 Ensembl | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:82195 Vergnes L, et al., A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res. 2003 Mar;44(3):503-11
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory