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Prmt7 Gene Detail
Summary
  • Symbol
    Prmt7
  • Name
    protein arginine N-methyltransferase 7
  • Synonyms
    4933402B05Rik, MGC:7929
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384879
    NCBI Gene: 214572
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106937686-106978326 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.11 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384879
 protein coding gene Chr8:106937568-106979426 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034080
 protein coding gene Chr8:108564874-108611693 (+)
A/J MGP_AJ_G0034061
 protein coding gene Chr8:104220973-104263297 (+)
AKR/J MGP_AKRJ_G0033987
 protein coding gene Chr8:107240930-107283271 (+)
BALB/cJ MGP_BALBcJ_G0034054
 protein coding gene Chr8:104402707-104444905 (+)
C3H/HeJ MGP_C3HHeJ_G0033766
 protein coding gene Chr8:107970287-108014507 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034574
 protein coding gene Chr8:112539920-112587608 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031516
 protein coding gene Chr8:97349405-97392854 (+)
CAST/EiJ MGP_CASTEiJ_G0033092
 protein coding gene Chr8:107497115-107544681 (+)
CBA/J MGP_CBAJ_G0033739
 protein coding gene Chr8:116156500-116208731 (+)
DBA/2J MGP_DBA2J_G0033894
 protein coding gene Chr8:103555101-103597225 (+)
FVB/NJ MGP_FVBNJ_G0033839
 protein coding gene Chr8:102489018-102530820 (+)
LP/J MGP_LPJ_G0033985
 protein coding gene Chr8:108770987-108813323 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033883
 protein coding gene Chr8:119340806-119386850 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034592
 protein coding gene Chr8:107199086-107240881 (+)
PWK/PhJ MGP_PWKPhJ_G0032793
 protein coding gene Chr8:102973933-103017148 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032634
 protein coding gene Chr8:105902673-105950079 (+)
WSB/EiJ MGP_WSBEiJ_G0033208
 protein coding gene Chr8:107886488-107932311 (+)



Homology
more
  • Human Ortholog
    PRMT7, protein arginine methyltransferase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRMT7, protein arginine methyltransferase 7
  • Synonyms
    SBIDDS
  • Links
    NCBI Gene ID: 54496
    neXtProt AC: NX_Q9NVM4
    UniProt: Q9NVM4

  • Chr Location
    16q22.1; chr16:68310951-68360870 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, increased epididymal fat pad weight, impaired myoblast differentiation, reduced satellite cells, early cellular replicative senescence in muscles and reduced muscle regeneration following injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    9
  • cDNA Data
    7
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214572 NCBI Gene Model | MGI Sequence Detail 40641 C57BL/6J ±  kb
    transcript NM_145404 RefSeq | MGI Sequence Detail 2269 FVB/N  
    polypeptide Q922X9 UniProt | EBI | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918262
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 27
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory