Mdm2<tm2.1Glo> Targeted Allele Detail MGI Mouse (MGI:2385439)

Mdm2^tm2.1Glo
Targeted Allele Detail

Summary

Symbol:	Mdm2^tm2.1Glo
Name:	transformed mouse 3T3 cell double minute 2; targeted mutation 2.1, Guillermina Lozano
MGI ID:	MGI:2385439
Synonyms:	FM
Gene:	Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Alliance:	Mdm2^tm2.1Glo page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:75118
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: The floxed neo cassette of Mdm2^tm2Glo was excised from intron 6 via germline expression of cre recombinase. Exons 5 and 6, encoding most of the Trp53-binding domain (residues 53 through 113), were left flanked by single loxP sites in introns 4 and 6. (J:75118)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	14 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mdm2^tm2.1Glo

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:	54 strains or lines available

References

Original:	J:75118 Grier JD, et al., Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb;32(2):145-7
All:	38 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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