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Trp63tm3.1Brd
Targeted Allele Detail
Summary
Symbol: Trp63tm3.1Brd
Name: transformation related protein 63; targeted mutation 3.1, Allan Bradley
MGI ID: MGI:2385473
Synonyms: p63flox
Gene: Trp63  Location: Chr16:25502513-25710842 bp, + strand  Genetic Position: Chr16, 17.37 cM
Alliance: Trp63tm3.1Brd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75125
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: The ubiquitous expression of cre recombinase resulted in the excision of the neo cassette from Trp63tm3Brd. Exons 5 through 7, encoding the DNA-binding domain, were left flanked by single loxP sites in introns 4 and 7. (J:75125)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:  60 strains or lines available
References
Original:  J:75125 Mills AA, et al., Conditional inactivation of p63 by Cre-mediated excision. Genesis. 2002 Feb;32(2):138-41
All:  20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory