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Pik3cdtm1.1Bvan
Targeted Allele Detail
Summary
Symbol: Pik3cdtm1.1Bvan
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; targeted mutation 1.1, Bart Vanhaesebroeck
MGI ID: MGI:2385596
Synonyms: P110deltaD910A, P110delta KI, PI3KdeltalD910A
Gene: Pik3cd  Location: Chr4:149733625-149787023 bp, - strand  Genetic Position: Chr4, 80.15 cM
Alliance: Pik3cdtm1.1Bvan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78412
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation details: This mutation is derived from Pik3cdtm1Bvan. Chimeric animals carrying Pik3cdtm1Bvan were crossed to a cre-expressing line to remove the floxed lacZ-neo cassette. The D910A mutation is left intact. Western blot analysis demonstrated the expression of mutant protein in thymocytes is similar to that of wild-type protein. Immunoprecipitates from homozygous mutant animals showed that mutant proteins were completely devoid of kinase activity. (J:78412)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pik3cd Mutation:  45 strains or lines available
References
Original:  J:78412 Okkenhaug K, et al., Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science. 2002 Aug 9;297(5583):1031-4
All:  73 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory