Myd88<tm1Aki> Targeted Allele Detail MGI Mouse (MGI:2385681)

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Myd88^tm1Aki
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Myd88^tm1Aki
Name:	myeloid differentiation primary response gene 88; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:2385681
Synonyms:	MyD88-, MyD88 KO
Gene:	Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
Alliance:	Myd88^tm1Aki page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:48832
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin selection cassette replaced a 1.0 kb genomic fragment that contained sequences encoding the C-terminal cytoplasmic domain of the protein. Northern blot analysis confirmed that the encoded mRNA could not be detected in the liver and spleen of homozygous mice. (J:48832, J:91950)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 9 strains available Cell Lines: 0 lines available
Carrying any Myd88 Mutation:	52 strains or lines available

References

Original:	J:48832 Adachi O, et al., Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 1998 Jul;9(1):143-50
All:	1416 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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