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Hoxa2tm2Fmr
Targeted Allele Detail
Summary
Symbol: Hoxa2tm2Fmr
Name: homeobox A2; targeted mutation 2, Filippo M Rijli
MGI ID: MGI:2385711
Synonyms: Hoxa2EGFP(lox-neo-lox)
Gene: Hoxa2  Location: Chr6:52139397-52141811 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance: Hoxa2tm2Fmr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75129
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A portion of exon 1, encoding the first 72 amino acids, was replaced via the insertion of the enhanced green fluorescent protein (EGFP) and a floxed neo cassette. Expression of EGFP was undetected, putatively due to the presence of the neo cassette. The deleted region corresponded to that in the conventionally targeted Hoxa2tm1Ipc. (J:75129)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa2 Mutation:  21 strains or lines available
References
Original:  J:75129 Pasqualetti M, et al., A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombination. Genesis. 2002 Feb;32(2):109-11
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory