Hsd11b1<tm1Yko> Targeted Allele Detail MGI Mouse (MGI:2385796)

Hsd11b1^tm1Yko
Targeted Allele Detail

Summary

Symbol:	Hsd11b1^tm1Yko
Name:	hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Yuri V Kotelevtsev
MGI ID:	MGI:2385796
Synonyms:	11beta-HSD-1-, 11beta-HSD1-, HSD1-
Gene:	Hsd11b1 Location: Chr1:192903917-192946345 bp, - strand Genetic Position: Chr1, 97.67 cM
Alliance:	Hsd11b1^tm1Yko page

Hsd11b1^tm1Yko/Hsd11b1^tm1Ykomice show lipid accumulation in the liver

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:37960
Parent Cell Line:	CGR8 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette containing a human beta actin promoter replaced a genomic sequence encompassing exons 3 and 4. Northern blot analyses of liver and brain did not detect mRNA in homozygous mutant mice. Enzyme function analyses of tissues from homozygous mutant mice detected less than 5% of wild-type enzyme levels in liver and did not detect enzyme in brain. (J:45085)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hsd11b1 Mutation:	28 strains or lines available

References

Original:	J:37960 Kotelevtsev YV, et al., Inactivation of 11 beta-hydroxysteroid dehydrogenase type 1 by gene targeting in mice. Endocr Res. 1996;22(4):791-792
All:	34 reference(s)

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