Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Myl2tm1(cre)Krc
Name:	myosin, light polypeptide 2, regulatory, cardiac, slow; targeted mutation 1, Kenneth R Chien
MGI ID:	MGI:2385922
Synonyms:	MLC-2v -, Mlc2v-cre, MLC2v-cre, MLC2vcreKI
Gene:	Myl2  Location: Chr5:122239014-122251535 bp, + strand  Genetic Position: Chr5, Syntenic
Alliance:	Myl2tm1(cre)Krc page

Germline Transmission:	Earliest citation of germline transmission: J:45125
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Myl2tm1(cre)Krc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Myl2 (MGI:97272)   Mutation details: Part of exon 1 and all of exon 2 were replaced with a cre gene and a floxed PGK-neo-tk cassette via homologous recombination. Western blot analysis showed that homozygous embryos did not express Myl2 protein product. The knocked in cre gene is expressed by the Myl2 promoter in ventricular tissue starting at day E7.5. (J:45125)

Activity:	Tissue activity of this recombinase allele
Driver:	Myl2 (mouse) Summary of all recombinase alleles driven by Myl2. Comparative matrix view of recombinase activities Alliance mouse Myl2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

25 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myl2 Mutation:	22 strains or lines available

Original:	J:45125 Chen J, et al., Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem. 1998 Jan 9;273(2):1252-6
All:	137 reference(s)