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Nfe2l2tm1Mym
Targeted Allele Detail
Summary
Symbol: Nfe2l2tm1Mym
Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Masayuki Yamamoto
MGI ID: MGI:2385925
Synonyms: Nfe2l2tm1Yin, nrf2 (-), Nrf2-
Gene: Nfe2l2  Location: Chr2:75505857-75534985 bp, - strand  Genetic Position: Chr2, 44.75 cM
Alliance: Nfe2l2tm1Mym page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41943
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A lacZ gene followed by a neomycin selection cassette was inserted in-frame into exon 5, and a 1.2 kb segment containing the rest of the exon 5 coding sequences was deleted. Northern blot analysis confirmed that no wild-type transcript is expressed from this allele. (J:41943)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 15 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Nfe2l2tm1Mym
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Nfe2l2 Mutation:  90 strains or lines available
References
Original:  J:41943 Itoh K, et al., An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22
All:  347 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
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