Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Tg(Pbsn-cre)4Prb Name: transgene insertion 4, Pradip Roy-Burman MGI ID: MGI:2385927 Synonyms: ARR2PB-Cre, PB-Cre, PbCre4, PB-Cre4 Transgene: Tg(Pbsn-cre)4Prb  Location: unknown   Alliance: Tg(Pbsn-cre)4Prb page

Prostate hyperplasia and low-grade prostate intraepithelial neoplasia in Brca2tm1Brn/Brca2tm1Brn Tg(Pbsn-cre)4Prb/0 mice Show the 9 phenotype image(s) involving this allele.

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Pbsn-cre)4Prb expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Pbsn (54193) Pbsn  (MGI:1860484)   Mutation details: The transgene is composed of the cre recombinase gene under the control of a composite promoter derived from rat Pbsn. The rat Pbsn promoter drives postnatal transgene expression in the prostatic epithelium. The transgene is expressed postnatally in prostatic epithelium with the highest level of expression in the lateral lobe of the prostate gland. A very low level of transgene expression was detected in the seminal vesicles, testes, and ovaries. No transgene expression was detected in any of the other tissue types examined. (J:68167)

Activity:	Tissue activity of this recombinase allele
Driver:	Pbsn (rat) Summary of all recombinase alleles driven by Pbsn. Comparative matrix view of recombinase activities Alliance rat Pbsn gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

104044 assay results 6 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(Pbsn-cre)4Prb

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:68167 Wu X, et al., Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev. 2001 Mar;101(1-2):61-9
All:	294 reference(s)