Nfe2l1<tm1Ywk> Targeted Allele Detail MGI Mouse (MGI:2385929)

Nfe2l1^tm1Ywk
Targeted Allele Detail

Summary

Symbol:	Nfe2l1^tm1Ywk
Name:	nuclear factor, erythroid derived 2,-like 1; targeted mutation 1, Yuet Wai Kan
MGI ID:	MGI:2385929
Synonyms:	Nrf-1 -, Nrf1r^PGK-neo
Gene:	Nfe2l1 Location: Chr11:96708240-96720794 bp, - strand Genetic Position: Chr11, 60.12 cM, cytoband D-E
Alliance:	Nfe2l1^tm1Ywk page

Abnormal development of Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk embryos with increased apoptosis

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:46990
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin selection cassette was inserted into the terminal exon which encodes the DNA binding and leucine zipper domains. Northern blot and RT-PCR analysis demonstrated that a mutant 7 kb transcript was expressed from this allele, but immunoblot analysis confirmed that no detectable protein was encoded by this allele. (J:46990)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Nfe2l1 Mutation:	42 strains or lines available

References

Original:	J:46990 Chan JY, et al., Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J. 1998 Mar 16;17(6):1779-87
All:	7 reference(s)

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