Nr2f1<tm1Mjts> Targeted Allele Detail MGI Mouse (MGI:2385930)

About Help FAQ

Nr2f1^tm1Mjts
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Nr2f1^tm1Mjts
Name:	nuclear receptor subfamily 2, group F, member 1; targeted mutation 1, Ming-Jer Tsai
MGI ID:	MGI:2385930
Synonyms:	COUP-TFI-, Coup-tfI mutant, mCOUP-TFI mutant
Gene:	Nr2f1 Location: Chr13:78337090-78346954 bp, - strand Genetic Position: Chr13, 41.38 cM
Alliance:	Nr2f1^tm1Mjts page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:42259
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Sequence encoding the amino terminus, the DNA binding domain, and a portion of the ligand binding domain was deleted by the insertion of neomycin selection cassette. Normal transcript was not detected by Northern blot analysis of homozygous mutant embryos. (J:42259)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	29 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Nr2f1 Mutation:	25 strains or lines available

References

Original:	J:42259 Qiu Y, et al., Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev. 1997 Aug 1;11(15):1925-37
All:	17 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24