P2rx7<tm1Gab> Targeted Allele Detail MGI Mouse (MGI:2386080)

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P2rx7^tm1Gab
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	P2rx7^tm1Gab
Name:	purinergic receptor P2X, ligand-gated ion channel, 7; targeted mutation 1, Christopher A Gabel
MGI ID:	MGI:2386080
Synonyms:	P2X7-, P2X7 KO, P2X7R^-, P2X7R^Delta506-532, Pfizer P2X7^-
Gene:	P2rx7 Location: Chr5:122781974-122829495 bp, + strand Genetic Position: Chr5, 62.5 cM, cytoband F
Alliance:	P2rx7^tm1Gab page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:66835
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Modified isoform(s))
Mutations:		Insertion, Intragenic deletion
		Mutation details: Sequence encoding amino acids 506 through 532 was replaced by the insertion of a neomycin selection cassette. Transcript was undetected by Northern blot analysis of bone marrow mast cells isolated from homozygous mutant mice. Western blot analysis of homozygous mutant peritoneal macrophages showed an absence of normal and truncated protein. Subsequent analysis found low levels of expression of the 13b isoform in the brain, salivary gland and spleen as well as a C-terminal truncated variant transcript. (J:66835, J:194518)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any P2rx7 Mutation:	54 strains or lines available

References

Original:	J:66835 Solle M, et al., Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem. 2001 Jan 5;276(1):125-32
All:	253 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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