Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Smarca4tm1Mag
Name:	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; targeted mutation 1, Terry Magnuson
MGI ID:	MGI:2386105
Synonyms:	Brg1-, Brg1null
Gene:	Smarca4  Location: Chr9:21527465-21615526 bp, + strand  Genetic Position: Chr9, 7.84 cM
Alliance:	Smarca4tm1Mag page

Germline Transmission:	Earliest citation of germline transmission: J:66861
Parent Cell Line:	CT129 (ES Cell)
Strain of Origin:	129S/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced sequence encoding part of the DNA-dependent ATPase domain. The deleted region encoded helicase motif 1, which contains the ATP binding site, and helicase motif 1a. The allele was expected to encode a chimeric protein, though while Northern blot analysis identified transcripts containing both endogenous and neo transgene elements, protein was undetected by Western blot analysis. (J:66861)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

List all tumor models in MMHCdb carrying Smarca4tm1Mag

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smarca4 Mutation:	110 strains or lines available

Original:	J:66861 Bultman S, et al., A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell. 2000 Dec;6(6):1287-95
All:	20 reference(s)