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Col15a1tm1Pih
Targeted Allele Detail
Summary
Symbol: Col15a1tm1Pih
Name: collagen, type XV, alpha 1; targeted mutation 1, Taina Pihlajaniemi
MGI ID: MGI:2386162
Synonyms: Col15a1-
Gene: Col15a1  Location: Chr4:47208161-47313167 bp, + strand  Genetic Position: Chr4, 26.01 cM, cytoband B1-B3
Alliance: Col15a1tm1Pih page
Col15a1tm1Pih/Col15a1tm1Pih muscles display areas of degeneration, regeneration and variation in fiber size

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67212
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: A loxP site was introduced ~900 bp upstream of exon 1 and a loxP-flanked neomycin resistance cassette 120 bp downstream of exon 2. Cre recombinase deleted exons 1 and 2, encoding the first 33 amino acids of the protein, and the selection cassette, leaving behind a single loxP site. This allele was derived from the same targeting event as Col15a1tm2.1Pih. The absence of transcript and protein was verified by Northern blot and immunohistochemical analyses of homozygous mutant mice. (J:67212)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Col15a1tm1Pih
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Col15a1 Mutation:  71 strains or lines available
References
Original:  J:67212 Eklund L, et al., Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1194-9
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory