Ogg1tm1Tno
Targeted Allele Detail
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| Symbol: |
Ogg1tm1Tno |
| Name: |
8-oxoguanine DNA-glycosylase 1; targeted mutation 1, Tetsuo Noda |
| MGI ID: |
MGI:2386212 |
| Synonyms: |
Mmh-, Ogg1- |
| Gene: |
Ogg1 Location: Chr6:113303959-113311149 bp, + strand Genetic Position: Chr6, 52.75 cM, cytoband E-F1
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| Alliance: |
Ogg1tm1Tno page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:61684
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Half of exon 2 and the entire exon 3 were replaced with a PGK-neo cassette via homologous recombination. Gene expression and enzyme activity is absent in liver extracts from homozygous mutant animals as shown by Northern blot analysis and enzyme assay.
(J:61684)
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View phenotypes and curated references for all genotypes (concatenated display).
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List all tumor models in MMHCdb carrying
Ogg1tm1Tno
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ogg1 Mutation: |
23 strains or lines available
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| Original: |
J:61684 Minowa O, et al., Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61 |
| All: |
7 reference(s) |
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Analysis Tools
