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Igf1rtm1.1Mhz
Targeted Allele Detail
Summary
Symbol: Igf1rtm1.1Mhz
Name: insulin-like growth factor I receptor; targeted mutation 1.1, Martin Holzenberger
MGI ID: MGI:2386328
Synonyms: Igf1rlox, IGF-1R/loxP, IGF-IRlox
Gene: Igf1r  Location: Chr7:67602575-67883416 bp, + strand  Genetic Position: Chr7, 37.27 cM
Alliance: Igf1rtm1.1Mhz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63460
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: The in vivo expression of cre recombinase via the EIIa promoter resulted in the excision of the floxed neo cassette from Igf1rtm1Mhz. Exon 3 was left intact and flanked by loxP sites. (J:63460)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1r Mutation:  88 strains or lines available
References
Original:  J:63460 Holzenberger M, et al., A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. Endocrinology. 2000 Jul;141(7):2557-66
All:  53 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory