Epas1tm1Fong
Targeted Allele Detail
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| Symbol: |
Epas1tm1Fong |
| Name: |
endothelial PAS domain protein 1; targeted mutation 1, Guo-Hua Fong |
| MGI ID: |
MGI:2386334 |
| Synonyms: |
EPAS-1 |
| Gene: |
Epas1 Location: Chr17:87061292-87140838 bp, + strand Genetic Position: Chr17, 56.9 cM
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| Alliance: |
Epas1tm1Fong page
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The majority of exon 2, which encodes the basic helix-loop-helix domain, was replaced with a cassette containing both IRES-lacZ and neo genes. Transcript was undetected by RT-PCR analyses of homozygous mutant embryos. Weak expression of beta-galactosidase, putatively due to the inefficiency of the IRES, showed the pattern of expression to recapitulate that of the endogenous gene.
(J:63415)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Epas1 Mutation: |
66 strains or lines available
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| Original: |
J:63415 Peng J, et al., The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8386-91 |
| All: |
5 reference(s) |
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Analysis Tools
