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Hmga2tm1Cha
Targeted Allele Detail
Summary
Symbol: Hmga2tm1Cha
Name: high mobility group AT-hook 2; targeted mutation 1, Kiran Chada
MGI ID: MGI:2386412
Synonyms: Hmgic-
Gene: Hmga2  Location: Chr10:120197180-120312374 bp, - strand  Genetic Position: Chr10, 67.94 cM
Alliance: Hmga2tm1Cha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28571
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3 kb region of the gene containing exons 1 and 2 was replaced with a PGK-neo cassette via homologous recombination. Homozygous mutants lack gene expression as demonstrated by Western blot analysis of day E12.5 embryos. (J:28571)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Hmga2tm1Cha
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmga2 Mutation:  12 strains or lines available
References
Original:  J:28571 Zhou X, et al., Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C [see comments]. Nature. 1995 Aug 31;376(6543):771-4
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory