Hmga2<tm1Cha> Targeted Allele Detail MGI Mouse (MGI:2386412)

Hmga2^tm1Cha
Targeted Allele Detail

Summary

Symbol:	Hmga2^tm1Cha
Name:	high mobility group AT-hook 2; targeted mutation 1, Kiran Chada
MGI ID:	MGI:2386412
Synonyms:	Hmgic^-
Gene:	Hmga2 Location: Chr10:120197180-120312374 bp, - strand Genetic Position: Chr10, 67.94 cM
Alliance:	Hmga2^tm1Cha page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:28571
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 3 kb region of the gene containing exons 1 and 2 was replaced with a PGK-neo cassette via homologous recombination. Homozygous mutants lack gene expression as demonstrated by Western blot analysis of day E12.5 embryos. (J:28571)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hmga2^tm1Cha

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hmga2 Mutation:	12 strains or lines available

References

Original:	J:28571 Zhou X, et al., Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C [see comments]. Nature. 1995 Aug 31;376(6543):771-4
All:	18 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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