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Foxa1tm1(cre)Sew
Targeted Allele Detail
Summary
Symbol: Foxa1tm1(cre)Sew
Name: forkhead box A1; targeted mutation 1, Susan E Waltz
MGI ID: MGI:2386437
Gene: Foxa1  Location: Chr12:57587414-57593702 bp, - strand  Genetic Position: Chr12, 24.7 cM
Alliance: Foxa1tm1(cre)Sew page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75503
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Foxa1tm1(cre)Sew expression driven by 1 gene
 
Mutation details: The majority of exon 2 was replaced with a cassette containing NLS-cre. While the endogenous promoter is active from E8-8.5 through adulthood in endoderm derived tissues, namely, the lung, liver, and gastrointestinal tract, the expression of the targeted allele was ubiquitous. (J:75503)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxa1 (mouse)
Summary of all recombinase alleles driven by Foxa1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxa1 Mutation:  21 strains or lines available
References
Original:  J:75503 Waltz SE, et al., Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses. J Clin Invest. 2001 Aug;108(4):567-76
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory