Wrn<tm1Lgu> Targeted Allele Detail MGI Mouse (MGI:2386438)

Wrn^tm1Lgu
Targeted Allele Detail

Summary

Symbol:	Wrn^tm1Lgu
Name:	Werner syndrome RecQ like helicase; targeted mutation 1, Leonard Guarente
MGI ID:	MGI:2386438
Synonyms:	WRN-
Gene:	Wrn Location: Chr8:33724412-33875555 bp, - strand Genetic Position: Chr8, 20.3 cM, cytoband A4
Alliance:	Wrn^tm1Lgu page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:61567
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The 3'-most exon encoding part of the catalytic helicase domain was replaced with a beta-geo cassette via homologous recombination. The null allele was confirmed by Western blot analysis of ear fibroblasts derived from homozygous mutant animals. No protein product was detected using antibodies directed against the N- and C-terminal regions of Wrn. (J:61567)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Wrn Mutation:	94 strains or lines available

References

Original:	J:61567 Lombard DB, et al., Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol. 2000 May;20(9):3286-91
All:	10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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