Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Tg(Nes-cre)1Wme
Name:	transgene insertion 1, Werner Muller
MGI ID:	MGI:2386545
Synonyms:	bal1, Bal1 cre, balancer1, Nestin-Cre, SLNE4c, Tg(balancer1)2Cgn, TgN(balancer1)1Cgn, TgN(balancer1)2Cgn
Transgene:	Tg(Nes-cre)1Wme  Location: unknown
Alliance:	Tg(Nes-cre)1Wme page

Strain of Origin:

(C57BL/6 x CBA)F2

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Nes-cre)1Wme expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Nes   Mutation details: The transgenic construct contained a nestin promoter followed by cre recombinase sequence adjoined to a nuclear localization signal. Intron 2 of the nestin gene was included upstream of a polyadenylation signal. While the endogenous nestin promoter is CNS-specific, Southern blot analysis showed the ubiquitous expression of cre in transgenic mice. Variable mosaicism/partial deletion of loxP-flanked alleles occurs before embryonic day 10.5, and it is detectable in all adult organs examined including germ line cells. (J:67926)

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (species not specified) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	98 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:67926 Betz UA, et al., Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curr Biol. 1996 Oct 1;6(10):1307-16
All:	63 reference(s)