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Tnip2 Gene Detail
Summary
  • Symbol
    Tnip2
  • Name
    TNFAIP3 interacting protein 2
  • Synonyms
    1810020H16Rik, ABIN-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386643
    NCBI Gene: 231130
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:34653440-34671323 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    576 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386643
 protein coding gene Chr5:34653431-34671335 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029465
 protein coding gene Chr5:32735118-32754159 (-)
A/J MGP_AJ_G0029432
 protein coding gene Chr5:31654722-31672450 (-)
AKR/J MGP_AKRJ_G0029381
 protein coding gene Chr5:32876707-32894446 (-)
BALB/cJ MGP_BALBcJ_G0029442
 protein coding gene Chr5:32189663-32207744 (-)
C3H/HeJ MGP_C3HHeJ_G0029164
 protein coding gene Chr5:32912544-32931685 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029896
 protein coding gene Chr5:34624703-34643102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027133
 protein coding gene Chr5:29434191-29453005 (-)
CAST/EiJ MGP_CASTEiJ_G0028573
 protein coding gene Chr5:31974489-31992924 (-)
CBA/J MGP_CBAJ_G0029132
 protein coding gene Chr5:35392741-35413307 (-)
DBA/2J MGP_DBA2J_G0029280
 protein coding gene Chr5:31825164-31842851 (-)
FVB/NJ MGP_FVBNJ_G0029239
 protein coding gene Chr5:31265770-31284724 (-)
LP/J MGP_LPJ_G0029365
 protein coding gene Chr5:33153087-33171692 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029269
 protein coding gene Chr5:36261718-36280174 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029929
 protein coding gene Chr5:32383832-32403326 (-)
PWK/PhJ MGP_PWKPhJ_G0028298
 protein coding gene Chr5:30969499-30986015 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028129
 protein coding gene Chr5:31822695-31841256 (-)
WSB/EiJ MGP_WSBEiJ_G0028654
 protein coding gene Chr5:32462369-32481171 (-)



Homology
more
  • Human Ortholog
    TNIP2, TNFAIP3 interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNIP2, TNFAIP3 interacting protein 2
  • Synonyms
    ABIN2, FLIP1, KLIP
  • Links
    NCBI Gene ID: 79155
    neXtProt AC: NX_Q8NFZ5
    UniProt: Q8NFZ5

  • Chr Location
    4p16.3; chr4:2741648-2756342 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    9 involving Tnip2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    23 strains or lines available
Mice homozygous for a null allele have impaired IL-1 response and macrophage physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    25
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 231130 NCBI Gene Model | MGI Sequence Detail 17884 C57BL/6J ±  kb
transcript NM_139064 RefSeq | MGI Sequence Detail 1966 C57BL/6  
polypeptide Q99JG7 UniProt | EBI | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916355, MGI:2140874
References
more
  • Summaries
    All 60
    Diseases 1
    Gene Ontology 8
    Phenotypes 33
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory