Abcc8<tm1Jbry> Targeted Allele Detail MGI Mouse (MGI:2386677)

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Abcc8^tm1Jbry
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Abcc8^tm1Jbry
Name:	ATP-binding cassette, sub-family C member 8; targeted mutation 1, Joseph Bryan
MGI ID:	MGI:2386677
Synonyms:	Sur1^-, Sur1KO
Gene:	Abcc8 Location: Chr7:45753952-45829441 bp, - strand Genetic Position: Chr7, 29.66 cM
Alliance:	Abcc8^tm1Jbry page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:61356
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The gene was disrupted by replacement of exon 2 with a puromycin resistance cassette via homologous recombination. Photolabeling of neuronal membranes from homozygous mutant animals did not detect protein product. (J:61356)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Abcc8 Mutation:	78 strains or lines available

References

Original:	J:61356 Seghers V, et al., Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion. J Biol Chem. 2000 Mar 31;275(13):9270-7
All:	32 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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